The Power of Synergy: Why Combo Trumps Single Extracts

  • A blend containing Reishi, Shiitake, and Maitake was the first to show synergistic effects, where the combined benefit exceeded that of each alone.

  • Studies using a Cordyceps-containing mushroom blend (e.g. PeakO₂) demonstrated superior performance in VO₂ max, endurance, and reduced fatigue compared to placebo.
  • Research supports mushroom + adaptogen synergy (e.g. Reishi + Ashwagandha) to deliver greater stress resilience, better hormonal balance, and broader benefits than each individually.

  • One study combining Lion’s Mane, Bacopa, and Ashwagandha showed a 29% increase in BDNF (brain‑derived neurotrophic factor), a 41% reduction in oxidative stress, and 17% boost in cognitive speed—all in a triple‑blind trial.

  • A systematic review emphasizes that using multiple adaptogenic mushrooms can help manage stress, enhance immunity, and promote mental wellness in a way that surpasses single‑ingredient use.
 Check the Science: What Makes LionZen™ So Powerful